• hkytara

TARA Seminar on Apr. 1st

A TARA seminar will be held as follows.

Date:Monday, April 1st, 2019 Time: 13:00-14:00 Venue: Seminar room, 2F, Bldg. A, TARA Center [Map

Speaker: James F.Martin,M.D., Ph.D.(Vivian L. Smith Professor of Regenerative MedicineDepartment of Molecular Physiology and  Biophysics,  Baylor College of Medicine, Houston, TX)

Subject: “Hippo-signaling in Heart Regeneration ”

Summary:The mammalian heart regenerates poorly, and damage commonly leads to heart failure. The Hippo pathway is an evolutionarily conserved kinase cascade that regulates heart size during development and prevents adult mammalian cardiomyocyte regeneration by inhibiting the transcription cofactor Yap. We identified Yap target genes that are activated during cardiomyocyte renewal and regeneration by performing chromatin immunoprecipitation sequencing (ChIP-Seq), mRNA expression profiling, and other genome-wide approaches in Hippo-deficient hearts. Our findings indicated that Yap regulates genes important for cell cycle progression, genes encoding proteins that promoteF-actin polymerization and link the actin cytoskeleton to extracellular matrix.I will discuss our latest findings that reveal new insights into heart regeneration.

Leach, JP et al. Nature 550:260-264 (2017).  Wang, J. et al. Nat Rev Cardiol15(11):672-684(2018). Monroe, TO et al. Dev Cell 48(6):765-779.e7(2019).

TARA Seminar poster - Dr.Jim



We have new member, Eri, junior in Medical Sciences, joined our lab in last November. Welcome Eri! We updated “Lab Members” page.

Our lab member, Ryutaro’s paper can be read on the website.  Please find the link below for the paper. R. Ishii, H. Yanagisawa*, A. Sada*: Defining compartmentalized stem cell populations with distin

A Review article by Yoshito and Hiromi has been published on the Clinical Science online website. Y. Yamashiro and H.Yanagisawa: The molecular mechanism of mechanotransduction in vascular homeostasis