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Complete List of Publications

2023

・Raja E, Clarin MTRDC, Yanagisawa H.

　Matricellular Proteins in the Homeostasis, Regeneration, and Aging of Skin. Invited Review

　Int J Mol Sci. 2023 Sep 19;24(18):14274. doi: 10.3390/ijms241814274.

 

・Deleeuw V, Carlson E, Renard M, Zientek KD, Wilmarth PA, Reddy AP, Manalo EC, Tufa SF, Keene DR, Olbinado M,

   Stampanoni M, Kanki S, Yanagisawa H, Mosquera LM, Sips P, De Backer J, Sakai LY.

　Unraveling the Role of TGFβ Signaling in Thoracic Aortic Aneurysm and Dissection Using Fbn1 Mutant Mouse Models.

　Matrix Biol. 2023 Sep 6:S0945-053X(23)00095-1. doi: 10.1016/j.matbio.2023.09.001. Online ahead of print.

 

 

・Nicolo Dubacher, Kaori Sugiyama, Jeffrey D. Smith, Vanessa Nussbaumer, MátéCsonka, Szilamér Ferenczi, Krisztina J. Kovács,

   Sylvan M. Caspar, Lisa Lamberti, Janine Meienberg, Hiromi Yanagisawa, Mary B. Sheppard, Gabor Matyas

　Novel Insights into the Aortic Mechanical Properties of Mice Modeling Hereditary Aortic Diseases

　bioRxiv 2023.08.15.553452; doi: https://doi.org/10.1101/2023.08.15.553452

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2022

  ・Y. Yamashiro*, K. Ramirez, K. Nagayama, N. Hattori, Y-Y. Liu, S. Matsunaga, S. Tomita, Y. Kubota, H. Yanagisawa*:

　  Partial endothelial-to-mesenchymal transition (EndMT) mediated by HIF-induced CD45 in neointima formation upon carotid         artery ligation.　Cardiovasc. Research, In Press.

  ・H. Sugiura*, J. Tsunezumi, H. Yanagisawa*, M. Futaya, K. Nitta, K. Tsuchiya:

　  Fibulin 7 aggravates calcium oxalate-induced acute kidney injury by binding to calcium oxalate crystals.

　  J. Cell. Physiol. https://doi.org/10.1002/jcp.30914

  ・Nguyen TAV, Antunes Lino C, Hang HT, Alves JV, Thang BQ, Shin SJ, Sugiyama K, Matsunaga H, Takayama H,  

    Yamashiro Y*, Yanagisawa H*: Protective role of endothelial fibulin-4 in valvulo-arterial integrity, JAHA In press.

  ・Raja E†, Changarathil G†, Oinam L†, Tsunezumi J, Ngo YX, Ishii R, Sasaki T, Imanaka-Yoshida K, Yanagisawa H*, Sada A*:

　  The extracellular matrix fibulin 7 maintains epidermal stem cell heterogeneity during skin aging. EMBO Rep. 2022 Oct. 24:e55478.

　  doi: 10.15252/embr.202255478.

  • Shiota T, Nagata R, Kikuchi S, Nanaura H, Matsubayashi M, Nakanishi M, Kobashigawa S, Kiriyama T, Nagayama K, Sugie K, Yamashiro Y*, Mori E*: C9orf72-derived proline:arginine poly-dipeptides modulate cytoskeleton and mechanical stress response. Front. Cell Dev. Biol., doi:10:750829, 2022. https://www.frontiersin.org/articles/10.3389/fcell.2022.750829/full

  • Garelnabi M, Cowdin M, Fang Y, Shrestha B, Ushio-Fukai M, Aikawa E, Graham G, Molema G, Yanagisawa H and Aikawa M (2022)  Embracing Diversity, Equity, and Inclusion in the Scientific Community—Viewpoints of the Diversity, Equity, and Inclusion Committee of the North American Vascular Biology Organization. Front. Cardiovasc. Med. 9:863256. doi: 10.3389/fcvm.2022.863256

  • YX. Ngo, K. Haga, A. Suzuki, H. Kato, H. Yanagisawa, K. Izumi, A. Sada :Isolation and Culture of Primary Oral Keratinocytes from the Adult Mouse Palate. J Vis Exp. 2021 Sep 24;(175). doi: 10.3791/62820.https://pubmed.ncbi.nlm.nih.gov/34633387/

  • MS. Bazzi, R. Balouchzadeh, SN. Pavey, JD. Quirk, H. Yanagisawa, V. Vedula, JE. Wagenseil, VH. Barocas : Experimental and Mouse-Specific Computational Models of the Fbln4 SMKO Mouse to Identify Potential Biomarkers for Ascending Thoracic Aortic Aneurysm. Cardiovasc Eng Technol. 2022 Jan 22. doi: 10.1007/s13239-021-00600-4. Online ahead of print.

  • Funato N* and Yanagisawa H: Tbx1 targets the miR-200-ZEB2 axis to include epithelial differentiation and inhibit stem cell properties. Scientific Reports. 12, Article number: 20188 (2022).

  • Editorial: Extracellular Matrix Dynamics in Biology, Bioengineering, and Pathology—Volume II: Loganathan R*, Yanagisawa H, Gentleman E, Little CD, Weiss JA, Frontiers Cell and Developmental Biology, In press.  

2021

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  • K. Kimura, M. Breitbach, FA.Schildberg, M. Hesse, BK. Fleischmann: Bone marrow CD73+ mesenchymal stem cells display increased stemness in vitro and promote fracture healing in vivo.  BoneReports. https://doi.org/10.1016/j.bonr.2021.101133

  • H. Yanagisawa and U. Yokoyama: Extracellular matrix-mediated remodeling and mechanotransduction in large vessels during development and disease. Cellular Signaling. Invited Review.  https://doi.org/10.1016/j.cellsig.2021.110104

  • K. Kimura, A. Ooms, K. Graf-Riesen, M. Kuppusamy, A. Unger, J. Schuld, J. Daerr, A. Lother, C. Geisen, Hein L,S. Takahashi, G. Li, W. Röll, W. Bloch, PFM. van der Ven, WA. Linke, SM. Wu, PF. Huesgen, J. Höhfeld,DO. Fürst, BK. Fleischmann, M. Hesse: Overexpression of human BAG3P209L in mice causes restrictive cardiomyopathy. Nat Commun. 2021 Jun 11;12(1):3575. https://www.nature.com/articles/s41467-021-23858-7

  • K. Sugiyama †, J. Marzi †, E. M. Brauchle, M. Ando, Y. Yamashiro, B. Ramkhelawon, K. Schenke-Layland *, H.Yanagisawa* : Raman Microspectroscopy and Imaging Reveal Novel Biomarkers Specific for Thoracic Aortic Aneurysms. Cell Reports Medicine.　https://doi.org/10.1016/j.xcrm.2021.100261

  • K. Kimura*, K. Ramirez*, T. A. V. Nguyen, Y. Yamashiro, A. Sada& H. Yanagisawa* : Contribution of PDGFRα‑positive cells in maintenance and injury responses in mouse large vessels. Scientific Reports (2021) 11:8683  https://www.nature.com/articles/s41598-021-88126-6

     

2020

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​2019

  • G.Changarathil, K.Ramirez, H.Isoda, A.Sada*, and H.Yanagisawa:Wild-type and SAMP8 mice show age-dependent changes in distinct stem cell compartments of the interfollicular epidermis. PLoS ONE 14(5): e0215908. (2019) [PubMed][Full Text]

  • J. Burger, N. van Vliet, P. van Heijningen, H. Kumra, G. J. Kremers, M. Alves, G. van Cappellen, H. Yanagisawa, D. P. Reinhardt, R. Kanaar, I. van der Pluijm, J. Essers: Fibulin-4 deficiency differentially affects cytoskeleton structure and dynamics as well as TGFβ signaling, Cellular Signaling. 58(2019)65-78 https://doi.org/10.1016/j.cellsig.2019.02.008

  • H. Kumra, V. Nelea, H. Hakami, A. Pagliuzza, J. Djokic, J. Xu, H. Yanagisawa, and D. P. Reinhardt: Fibulin-4 exerts a dual role in LTBP-4L mediated matrix assembly and function. PNAS. [PubMed][Full Text]

  • K. Sugiyama, H. Horigome, L. Lin, T. Murakami, J. Shiono, Y. Yamashiro, H. Matsuura, H. Yoda, H. Yanagisawa: Novel ELN mutation in a Japanese family with a severe form of supravalvular aortic stenosis. Molecular Gennetics & Genomic Medicine.  [PubMed][Full Text]

  • S.Shin,H.Yanagisawa:Recent updates on the molecular network of elastic fiber formation. Essays In Biochemistry, EBC20180052.ReviewArticle(pdf)[ESSAYS IN BIOCHEMISTRY(Abstract)]

  • L.Oinam, G.Changarathil, YX.Ngo, H.Yanagisawa, A.Sada:Epidermal stem cell lineages. Advances in Stem Cells and their Niches, Volume 3(2019)[ScienceDirect(Abstract)]

  • H. Yanagisawa and J. Wageseil: Elastic fibers and biomechanics of the aorta: Insights from mouse studies. Matrix Biology(85-86):160-172(2020).Pub ahead of print(2019).https://doi.org/10.1016/j.matbio.2019.03.001

2018

  • Y. Yamashiro, B. Q. Thang, S. Shin, C. A. Lino, T. Nakamura, J. Kim, K. Sugiyama, C. Tokunaga, H. Sakamato, M. Osaka, E. C. Davis, J. E. Wagenseil, Y. Hiramatsu, and H. Yanagisawa: Role of thrombospondin-1 in mechanotransduction and development of thoracic aortic aneurysm in mouse and humans. Circ. Res. 123(6):660-672. DOI: 10.1161/CIRCRESAHA.118.313105. (2018).  [PubMed][Full Text]

  • I. van der Pluijm, J. Burger, P. M. van Heijningen, A. IJpma, N. van Vliet, C. Milanese, K. Schoonderwoerd, W. Sluiter, L. J. Ringuette, D. H. W. Dekkers, I. Que, E. L. Kaijzel, L. te Riet, E. MacFarlane, D. Das, R. van der Linden, M. Vermeij, J. A. Demmers, P. G. Mastroberardino, E. C. Davis, H. Yanagisawa, H. Dietz, R. Kanaar, and J. Essers: Decreased mitochondrial respiration in aneurysmal aortas of Fibulin-4 mutant mice is linked to PGC1A regulation. Cardiovasc Res. 114(13):1776-1793. DOI: 10.1093/cvr/cvy150. (2018).  [PubMed][Full Text]

  • J. Tsunezumi, H. Sugiura, L. Oinam, A. Ali, B. Q. Thang, A. Sada, Y. Yamashiro, M. Kuro-O, and H. Yanagisawa: Fibulin-7, a heparin binding matricellular protein, promotes renal tubular calcification in mice. Matrix Biol. DOI: 10.1016/j.matbio.2018.04.014. Epub ahead of print. (2018).  [PubMed][Full Text]

  • D. B. Manders, H.A. Kishore, A. F. Gazdar, P. W. Keller, J. Tsunezumi, H. Yanagisawa, J. Lea, and R. A. Word: Dysregulation of fibulin-5 and matrix metalloproteases in epithelial ovarian cancer. Oncotarget. 9(18):14251-14267 (2018). [PubMed][Full Text]

  • N. Funato and H. Yanagisawa: Deletion of the T-box transcription factor gene, Tbx1, in mice induces differential expression of genes associated with cleft palate in humans. Arch. Oral Biol. 95:149-155. DOI: 10.1016/j.archoralbio.2018.08.001. Epub ahead of print. (2018) [PubMed][Full Text]

2017

  • J. Kim, M. C. Staiculescu, A. J. Cocciolone, H. Yanagisawa, R. P. Mecham, and J. E. Wagenseil: Crosslinked elastic fibers are necessary for low energy loss in the ascending aorta. J. Biomechanics 61:199-207 (2017). [PubMed][Full Text]

  • C. W. Kim, A. Pokutta-Paskaleva, S. Kumar, L. H. Timmins, A. D. Morris, D. W. Kang, S. Dalal, T. Chadid, K. M. Kuo, J. Raykin, H. Li, H. Yanagisawa, R. L. Gleason, Jr., H. Jo, and L. P. Brewster: Disturbed flow promotes arterial stiffening through thrombospondin-1 (TSP-1). Circulation. 136(13):1217-1232 (2017). [PubMed][Full Text]

  • A. Sada, P. Jain, S. Wang, E. Leung, and T. Tumbar: Slc1a3-CreER as a Targeting Tool for the K6+ Epithelial Stem Cell Niche and its Precursors during Mouse Hair Follicle Cycle. J. Invest. Dermatol. 137(7):1569-1571 (2017). [PubMed][Full Text]

  • C. Bellini, M. R. Bersi, A. W. Caulk, J. Ferruzzi, D. M. Milewicz, F. Ramirez, D. B. Rifkin, G. Tellides, H. Yanagisawa, and J. D. Humphrey: Comparison of 10 murine models reveals a distinct biomechanical phenotype in thoracic aortic aneurysms. J. R. Soc. Interface. 14(130). DOI: 10.1098/rsif.2016.1036 (2017). [PubMed][Full Text]

  • T. Okuyama, J. Shirakawa, H. Yanagisawa, M. Kyohara, S. Yamazaki, K. Tajima, Y. Togashi, and Y. Terauchi: Identification of the matricellular protein Fibulin-5 as a target molecule of glucokinase-mediated calcineurin/NFAT signaling in pancreatic islets. Sci. Rep. 7:2364 (2017).  [PubMed][Full Text]

  • Y. Nakada, D. C. Canseco, S. Thet, S. Abdisalaam, A. Asaithaymby, C. X. Santos, A. Shah, H. Zhang, J. E. Faber, M. T. Kinter, L. I. Szweda, C. Xing, R. Deberardinis, O. Oz, Z. Lu, C. C. Zhang, W. Kimura#, and H. A. Sadek#: Hypoxia induces heart regeneration in adult mice. Nature 541 (7636):222-227. DOI: 10.1038/nature20173. (2017). [PubMed][Full Text]

  • Y. Yamashiro and H. Yanagisawa: Crossing Bridges between Extra- and Intra-Cellular Events in Thoracic Aortic Aneurysms. J. Atheroscler. Thromb. 25(2):99-110 (2017) [PubMed][Full Text]

2016

  • N. Funato, H. Kokubo, M. Nakamura, H. Yanagisawa, and Y. Saga: Specification of jaw identity by the Hand2 transcription factor. Sci. Rep. 6:28405 (2016). [PubMed][Full Text]

  • A. Sada, F. Jacob, E. Leung, S. Wang, B. S. White, D. Shalloway, and T. Tumbar: Defining the cellular lineage hierarchy in the interfollicular epidermis of adult skin. Nature Cell Biology. 18(6):619-631 (2016). [PubMed] [Full Text]

  • S.-I. Murtada, J. Ferruzzi, H. Yanagisawa, and J. D. Humphrey: Reduced biaxial contractility in the descending thoracic aorta of fibulin-5 deficient mice. J. Biomech. Eng. 138(5):051008 (2016). [PubMed][Full Text]

  • J. Ferruzzi, M. R. Bersi, R. P. Mecham, F. Ramirez, H. Yanagisawa, G. Tellides, and J. D. Humphrey: Loss of elastic fiber integrity compromises common carotid artery function: Implications for vascular aging. Artery Res. 14: 41-52 (2016). [PubMed][Full Text]

  • J. T. Benjamin, R. van der Meer, A. M. Im, E. J. Plosa, R. Zaynagetdinov, A. Burman, L. A. Gleaves, V. V. Polosukhin, G. H. Deutsch, H. Yanagisawa, J. M. Davidson, L. S. Prince, L. R. Young, and T. S. Blackwell: Epithelial-Derived Inflammation Disrupts Elastin Assembly and Alters Saccular Stage Lung Development. Am. J. Pathol. 186(7):1786–1800 (2016). [PubMed] [Full Text]

  • K. Chin*, C. Wieslander*, H. Shi, S. Balgobin, T. I. Montoya, H. Yanagisawa#, and R. Ann Word#: Pelvic organ support in animals with partial loss of fibulin-5 in the vaginal wall. PLoS One. 11(4): e0152793 (2016).　* co-first author, # co-senior author [PubMed][Full Text]

2015

  • M. Wang, M. Topalovski, J. E. Toombs, C. M. Wright, Z. R. Moore, D. A. Boothman, H. Yanagisawa, H. Wang, A. Witkiewicz, D. H. Castrillon, and R. A. Brekken: Fibulin-5 blocks microenvironmental ROS in pancreatic cancer. Cancer Res. 75(23):5058-5069 (2015). [PubMed][Full Text]

  • F. Kocabas, L. Xie, J. Xie, Z. Yu, R. J. DeBerardinis, W. Kimura, S. Thet, A. F. Elshamy, H. Abouellail, S. Muralidhar, X. Liu, C. Chen, H. A. Sadek, C. C. Zhang, and J. Zheng: Hypoxic metabolism in human hematopoietic stem cells. Cell Biosci. 5:39 (2015). [PubMed][Full Text]

  • Y. Nakada, W. Kimura, and H. A. Sadek: Defining the Limit of Embryonic Heart Regeneration. Circulation. 132(2):77-78 (2015). [PubMed][Full Text]

  • W. Kimura, F. Xiao, D. C. Canseco, S. Muralidhar, S. Thet, H. M. Zhang, Y. Abderrahman, R. Chen, J. A. Garcia, J. M. Shelton, J. A. Richardson, A. M. Ashour, A. Asaithamby, H. Liang, C. Xing, Z. Lu, C. C. Zhang, and H. A. Sadek: Hypoxia fate mapping identifies cycling cardiomyocytes in the adult heart. Nature. 523(7559):226-230 (2015). [PubMed][Full Text]

  • Y. Yamashiro, C. L. Papke, J. Kim, L.-J. Ringuette, Q.-J. Zhang, Z.-P. Liu, H. Mirzaei, J. E. Wagenseil, E. C. Davis, and H. Yanagisawa: Abnormal mechanosensing and cofilin activation promote the progression of ascending aortic aneurysms in mice. Sci. Signal. 8(399): ra105 (2015). [PubMed][Summary][Abstract][Full Text (No membership required/free to view from this link)]

  • C. L. Papke, J. Tsunezumi, L.-J. Ringuette, H. Nagaoka, M. Terajima, Y. Yamashiro, G. Urquhart, M. Yamauchi, E. C. Davis, and H. Yanagisawa: Loss of fibulin-4 disrupts collagen synthesis and maturation: Implications for pathology resulting from EFEMP2 mutations. Hum. Mol. Genet. 24(20):5867-5879 (2015). [PubMed][Full Text]

  • J. Kim, J. D. Procknow, H. Yanagisawa, and J. E. Wagenseil: Differences in genetic signaling, and not mechanical properties of the wall, are linked to ascending aortic aneurysms in Fibulin-4 knockout mice. Am. J. Physiol. Heart Circ. Physiol. 309(1):H103-H113 (2015). [PubMed][Full Text]

  • J. Ferruzzi, M. R. Bersi, S. Uman, H. Yanagisawa, and J. D. Humphrey: Decreased elastic energy storage, not increased material stiffness, characterizes central artery dysfunction in fibulin-5 deficiency independent of sex. J. Biomech. Eng. 137(3):031007 (2015). [PubMed] [Full Text]

  • V. Le, J. K. Cheng, J. Kim, M. C. Staiculescu, S. W. Ficker, S. C. Sheth, S. A. Bhayani, R. P. Mecham, H. Yanagisawa, and J. E. Wagenseil: Mechanical factors direct mouse aortic remodeling during early maturation. J. R. Soc. Interface 12(104):20141350 (2015). [PubMed] [Full Text]

  • N. Funato, M. Nakamura, and H. Yanagisawa: Molecular basis of cleft palates in mice. World J. Biol. Chem. 6(3):121-138 (2015). [PubMed][Full Text]

  • C. L. Papke, Y. Yamashiro, and H. Yanagisawa: MMP17/MT4-MMP and thoracic aortic aneurysms: OPNing new potential for effective treatment. Circ. Res. 117: 109-112 (2015).  [PubMed][Full Text]

2014

  • M. G. Espinosa, W. S. Gardner, L. Bennett, B. A. Sather, H. Yanagisawa, and J. E. Wagenseil: The effects of elastic fiber protein insufficiency and treatment on the modulus of arterial smooth muscle cells. J. Biomech. Eng. 136(2):021030 (2014). [PubMed] [Full Text]

  • V. P. Le, Y. Yamashiro, H. Yanagisawa, and J. E. Wagenseil: Measuring, reversing, and modeling the mechanical changes due to the absence of Fibulin-4 in mouse arteries. Biomech. Model Mechanobiol. 13(5):1081-1095 (2014). [PubMed] [Full Text]

  • V. P. Le, K. V. Stoka, H. Yanagisawa, and J. E. Wagenseil: Fibulin‐5 null mice with decreased arterial compliance maintain normal systolic left ventricular function, but not diastolic function during maturation. Physiol. Rep. 2(3):e00257 (2014). [PubMed] [Full Text]

  • N. Funato, M. Nakamura, J. A. Richardson, D. Srivastava, and H. Yanagisawa: Loss of Tbx1 induces bone phenotypes similar to cleidocranial dysplasia. Hum. Mol. Genet. 24(2):424-435 (2014). [PubMed] [Full Text]

  • N. W. M. Ramnath, K. M. van de Luijtgaarden, I. van der Pluijm, M. van Nimwegen, P. M. van Heijningen, S. M. A. Swagemakers, B. S. van Thiel, R. Y. Ridwan, N. van Vliet, M. Vermeij, L. J. A. C. Hawinkels, A. de Munck, O. Dzyubachyk, E. Meijering, P. van der Spek, R. Rottier, H. Yanagisawa, R. W. Hendriks, R. Kanaar, E. V. Rouwet, A. Kleinjan, and J. Essers: Extracellular matrix defects in aneurysmal fibulin-4 mice predispose to lung emphysema. PLoS One 9(9):e106054 (2014). [PubMed] [Full Text]

  • C. L. Papke and H. Yanagisawa: Fibulin-4 and fibulin-5 in elastogenesis and beyond: Insights from mouse and human studies. Matrix Biol. 37:142-149 (2014). [PubMed] [Full Text]

​2013

  • J. Huang, Y. Yamashiro, C. L. Papke, Y. Ikeda, Y. Lin, M. Patel, T. Inagami, V. P. Le, J. E. Wagenseil, and H. Yanagisawa: Angiotensin-converting enzyme-induced activation of local angiotensin signaling is required for ascending aortic aneurysms in fibulin-4-deficient mice. Sci. Transl. Med. 5(183):183ra58 (2013). [PubMed] [Full Text (PubMed)] [Abstract]

  • M. Budatha, S. Silva, T. I. Montoya, A. Suzuki, S. Shah-Simpson, C. K. Wieslander, M.Yanagisawa, R. A. Word, and H. Yanagisawa: Dysregulation of protease and protease inhibitors in a mouse model of human pelvic organ prolapse. PloS One 8(2): e56376 (2013). [PubMed] [Full Text]

2012

  • N. Funato, M. Nakamura, J. A. Richardson, D. Srivastava, and H. Yanagisawa: Tbx1 regulates oral epithelial adhesion and palatal development. Hum. Mol. Genet. 21 (11):2524-2537 (2012). [Pub Med] [Full Text]

  • A. Kapustin, V. Stepanova, N. Aniol, D. B. Cines, A. Poliakov, S. Yarovoi, T. Lebedeva, R. Wait, G. Ryzhakov, Y. Parfyonova, Y. Gursky, H. Yanagisawa, M. Minashkin, R. Beabealashvilli, A. Vorotnikov, A. Bobik, and V. Tkachuk: Fibulin-5 binds urokinase-type plasminogen activator and mediates urokinase-stimulated β1-integrin-dependent cell migration. Biochem. J. 443 (2):491-503 (2012). [PubMed] [Full Text]

2011

  • H. D. Møller, U. Ralfkjær, N. Cremers, M. Frankel, R. T. Pedersen, J. Klingelhöfer, H. Yanagisawa, M. Grigorian, P. Guldberg, J. Sleeman, E. Lukanidin, and N. Ambartsumian: Role of fibulin-5 in metastatic organ colonization. Mol. Cancer Res. 9 (5):553-563 (2011). [PubMed] [Full Text]

  • M. Budatha, S. Roshanravan, Q. Zheng, C. Weislander, S. L. Chapman, E. C. Davis, B. Starcher, R. A. Word, and H. Yanagisawa: Extracellular matrix proteases contribute to progression of pelvic organ prolapse in mice and humans. J. Clin. Invst. 121(5): 2048–2059 (2011). (Featured in commentary in the same issue of JCI and June 21 issue of NEJM). [PubMed] [Full Text]

​2010

  • W. Wan, H. Yanagisawa, and R. L. Gleason Jr.: Biomechanical and microstructural properties of common carotid arteries from fibulin-5 null mice. Ann. Biomed. Eng. 38 (12):3605-3617 (2010). [PubMed] [Full Text]

  • Y. Y. Kisanuki, N. Emoto, T. Ohuchi, B. Widyantoro, K. Yagi, K. Nakayama, R. M. Kedzierski, R. E. Hammer, H. Yanagisawa, S. C. Williams, J. A. Richardson, T. Suzuki, and M. Yanagisawa: Low blood pressure in endothelial cell-specific endothelin 1 knockout mice. Hypertension 56(1):121-128 (2010). [PubMed] [Full Text]

  • M. K. Schluterman, S. L. Chapman, G. Korpanty, K. Ozumi, T. Fukai,  H. Yanagisawa, and R. A. Brekken: Loss of fibulin-5 binding to β1 integrins inhibits tumor growth by increasing the level of ROS. Dis. Model. Mech. 3(5-6): 333-342 (2010). [PubMed] [Full Text]

  • J. Huang, E. C. Davis, S. L. Chapman, M. Budatha, L. Y. Marmorstein, R. A. Word, and H. Yanagisawa: Fibulin-4 deficiency results in ascending aortic aneurysms: a potential link between abnormal smooth muscle cell phenotype and aneurysm progression. Circ. Res. 106 (3): 583-592 (2010). [PubMed] [Full Text]

  • S. L. Chapman, F.-X. Sicot, E. C. Davis, J. Huang, T. Sasaki, M.-L. Chu, and H. Yanagisawa: Fibulin-2 and fibulin-5 cooperatively function to form the internal elastic lamina and protect from vascular injury. Arterioscler. Thromb. Vasc. Biol. 30(1):68-74 (2010). [PubMed] [Full Text]

  • H. Yanagisawa and E. C. Davis: Unraveling the mechanism of elastic fiber assembly: The roles of short fibulins. Int. J. Biochem. Cell Biol. 42(7): 1084–1093 (2010). [PubMed] [Full Text]

​2009

  • J. Choi, A. Bergdahl, Q. Zheng, B. Starcher, H. Yanagisawa, and E. C. Davis: Analysis of dermal elastic fibers in the absence of fibulin-5 reveals potential roles for fibulin-5 in elastic fiber assembly. Matrix Biol. 28(4):211-20 (2009). [PubMed] [Full Text]

  • N. Liu, A. C. Barbosa, S. L. Chapman, S. Bezprozvannaya, X. Qi, J. A. Richardson, H. Yanagisawa, and E. N. Olson: DNA binding-dependent and -independent functions of the Hand2 transcription factor during mouse embryogenesis. Development 136(6):933-942 (2009). [PubMed] [Full Text]

  • N. Funato, S. L. Chapman, M. D. McKee, H. Funato, J. A. Morris, J. M. Shelton, J. A. Richardson, and H. Yanagisawa: Hand2 controls osteoblast differentiation in the branchial arch by inhibiting DNA binding of Runx2. Development 136(4):615-625 (2009) (Featured in “In this Issue”). [PubMed][Full Text]

  • C. K. Wieslander, D. D. Rahn, D. D. McIntire, J. F. Acevedo, P. G. Drewes, H. Yanagisawa, and R. A. Word: Quantification of pelvic organ prolapse in mice: vaginal protease activity precedes increased MOPQ scores in fibulin 5 knockout mice. Biol. Reprod. 80(3):407-414 (2009). [PubMed] [Full Text]

  • H. Yanagisawa, M. K. Schluterman, R. A. Brekken: Fibulin-5, an integrin-binding matricellular protein: its function in development and disease. J. Cell Commun. Signal.  3(3-4):337-347 (2009). [PubMed] [Full Text]

2007

  • A. C. Barbosa, N. Funato, S. Chapman, M. D. McKee, J. A. Richardson, E. N. Olson, and H. Yanagisawa: Hand transcription factors cooperatively regulate development of the distal midline mesenchyme. Dev. Biol. 310(1):154-168 (2007). [PubMed] [Full Text]

  • K. M. Sullivan, R. Bissonnette, H. Yanagisawa, S. N. Hussain, and E. C. Davis: Fibulin-5 functions as an endogenous angiogenesis inhibitor. Lab. Invest. 87(8): 818-827 (2007). [PubMed] [Full Text]

  • P. G. Dewes, H. Yanagisawa, B. Starcher, I. Hornstra, K. Csiszar, S. I. Marinis, P. Keller, and R. A. Word: Pelvic organ prolapse in fibulin-5 knockout mice: pregnancy-induced changes in elastic fiber homeostasis in mouse vagina. Am. J. Pathol. 170(2): 578-589 (2007). [PubMed] [Full Text]

  • Q. Zheng, E. C. Davis, J. A. Richardson, B. C. Starcher, T. Li, R. D. Gerard, and H. Yanagisawa: Molecular analysis of fibulin-5 function during de novo synthesis of elastic fibers. Mol. Cell. Biol. 27(3): 1083-1095 (2007).  [PubMed] [Full Text]

2006

  • Q. Zheng, J. Choi, L. Rouleau, R. L. Leask, J. A. Richardson, E. C. Davis, and H. Yanagisawa: Normal wound healing in mice deficient for fibulin-5, an elastin binding protein essential for dermal elastic fiber assembly. J. Invest. Dermatol. 126(12): 2707-2714 (2006). (Featured in Commentary). [PubMed] [Full Text]

2005

  • S. L. Merklinger, R. A. Wagner, E. Spiekerkoetter, A. Hinek, R. H. Knutsen, M. G. Kabir, K. Desai, S. Hacker, L.Wang, G. M. Cann, N. S. Ambartsumian, E. Lukanidin, D. Bernstein, M. Husain, R. P. Mecham, B. Starcher, H. Yanagisawa, and M. Rabinovitch: Increased fibulin-5 and elastin in S100A4/Mts1 Mice with pulmonary hypertension. Circ. Res. 97(6):596-604 (2005). [PubMed] [Full Text]

  • Z.-P. Liu, Z. Wang, H. Yanagisawa, and E. N. Olson: Phenotypic modulation of smooth muscle cells through interaction of Foxo4 and myocardin. Dev. Cell 9(2):261-270 (2005). [PubMed] [Full Text]

  • J. A. Spencer, S. L. Hacker, E. C. Davis, R. P. Mecham, R. H. Knutsen, D. Y. Li, R. D. Gerard, J. A. Richardson, E. N. Olson, and H. Yanagisawa: Altered vascular remodeling in fibulin-5-deficient mice reveals a role of fibulin-5 in smooth muscle cell proliferation and migration. Proc. Natl. Acad. Sci. USA 102(8):2946-2951 (2005). [PubMed] [Full Text]

2004

  • J. Yu, S. Mcleans, H. Yanagisawa, C. P. Winlove, S. Roberts, R. P. Mecham, and J. Urban: The importance of elastin and fibulin-5 on spine development: a study of elastin KO and fibulin-5 KO on the development of vertebral body and intervertebral disc. Int. J. Exp. Pathol. 85(1): A29-A30. (2004). [Abstract] [Full Text PDF]

  • A. D. Nguyen, S. Itoh, V. Jeney, H. Yanagisawa, M. Fujimoto, M. Ushio-Fukai, and T. Fukai: Fibulin-5 is a novel binding protein for extracellular superoxide dismutase. Circ. Res. 95(11):1067-1074 (2004). [PubMed] [Full Text]

  • X. Liu, Y. Zhao, J. Gao, B. Pawlyk, B. Starcher, J. A. Spencer, H. Yanagisawa, J. Zuo, and T. Li: Elastic fiber homeostasis requires lysyl oxidase-like 1 protein. Nat. Genet. 36(2):178-182 (2004). [PubMed] [Full Text]

2003

  • M. Morishima, H. Yanagisawa, M. Yanagisawa, and A. Baldini: Ece1 and Tbx1 define distinct pathways to aortic arch morphogenesis. Dev. Dyn. 228(1):95-104 (2003). [PubMed] [Full Text]

  • L.-B. Ruest, M. Dager, H. Yanagisawa, J. Charité, R. E. Hammer, E. N. Olson, M. Yanagisawa, and D. E. Clouthier: dHAND-Cre transgenic mice reveal specific potential functions of dHAND during craniofacial development. Dev. Biol. 257(2):263-277 (2003). [PubMed] [Full Text]

  • H. Yanagisawa, D. E. Clouthier, J. A. Richardson, J. Charité, and E. N. Olson: Targeted deletion of a branchial arch-specific enhancer reveals a role of dHAND in craniofacial development. Development 130(6):1069-1078 (2003). [PubMed] [Full Text]

2002

  • H. Yanagisawa*, E. C. Davis, B. C. Starcher, T. Ouchi, M. Yanagisawa, J. A. Richardson, and E. N. Olson*: Fibulin-5 is an elastin-binding protein essential for elastic fibre development in vivo. Nature 415:168-171 (2002) (Previewed in Current Biology and reviewed in Nature Reviews Molecular Cell Biology). * Co-corresponding author  [PubMed] [Full Text]

Before 2001

  • Z.-P. Liu, O. Nakagawa, M. Nakagawa, H. Yanagisawa, R. Passier, J. A. Richardson, D. Srivastava, and E. N. Olson: CHAMP, a novel cardiac-specific helicase regulated by MEF2C. Dev. Biol. 234(2):497-509 (2001). [PubMed] [Full Text PDF]

  • O. Nakagawa, D. G. McFadden, M. Nakagawa, H. Yanagisawa, T. Hu, D. Srivastava, and E. N. Olson: Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling. Proc. Natl. Acad. Sci. USA 97 (25):13655-13660 (2000). [PubMed] [Full Text]

  • J. Rice, B. Doggett, D. A. Sweetser, H. Yanagisawa, M. Yanagisawa, and R. P. Kapur: Transgenic rescue of aganglionosis and piebaldism in lethal spotted mice. Dev. Dyn. 217(1):120-132 (2000). [PubMed] [Full Text]

  • D. E. Clouthier, S. C. Williams, H. Yanagisawa, M. Wieduwilt, J. A. Richardson, and M. Yanagisawa: Signaling pathways crucial for craniofacial development revealed by endothelin-A receptor-deficient mice. Dev. Biol. 217(1):10-24 (2000). [PubMed] [Full Text PDF]

  • H. Yanagisawa, R. E. Hammer, J. A. Richardson, N. Emoto, S. C. Williams, S. Takeda, D. E. Clouthier, and M. Yanagisawa: Disruption of ECE-1 and ECE-2 reveals a role for endothelin-converting enzyme-2 in murine cardiac development. J. Clin. Invst. 105(10):1373-1382 (2000). [PubMed] [Full Text]

  • Q. Lin, J. Lu, H. Yanagisawa, R. Webb, G. E. Lyons, J. A. Richardson, and E. N. Olson: Requirement of the MADS-box transcription factor MEF2C for vascular development. Development 125(22):4565-4574 (1998). [PubMed] [Full Text PDF]

  • N. Berthiaume, M. Yanagisawa, H. Yanagisawa, D. deWit, and P. D’Orléans-Juste: Pharmacology of endothelins in vascular circuits of normal or heterozygous endothelin-A or endothelin-B knockout transgenic mice. J. Cardiovasc. Pharmacol. 31 Suppl. 1:S561-S564 (1998). [PubMed] [Full Text]

  • D. E. Clouthier, K. Hosoda, J. A. Richardson, S. C. Williams, H. Yanagisawa, T. Kuwaki, M. Kumada, R. E. Hammer, and M. Yanagisawa: Cranial and cardiac neural crest defects in endothelin-A receptor-deficient mice. Development 125(5):813-824 (1998). [PubMed] [Full Text PDF]

  • H. Yanagisawa, R. E. Hammer, J. A. Richardson, S. C. Williams, D. E. Clouthier, and M. Yanagisawa: Role of endothelin-1/endothelin-A receptor-mediated signaling pathway in the aortic arch patterning in mice. J. Clin. Invst. 102(1):22-33 (1998). [PubMed ] [Full Text PDF]

  • H. Yanagisawa, M. Yanagisawa, R. P. Kapur, J. A. Richardson, S. C. Williams, D. E. Clouthier, D. de Wit, N. Emoto, and R. E. Hammer: Dual genetic pathways of endothelin-mediated intercellular signaling revealed by targeted disruption of endothelin converting enzyme-1 gene. Development 125(5):825-836 (1998). [PubMed] [Full Text PDF]

  • H. Yanagisawa, J. A. Richardson, J. D. Taurog, and R. E. Hammer: Characterization of psoriasiform and alopecic skin lesions in HLA-B27 transgenic rats. Am. J. Pathol. 147(4):955-964 (1995). [PubMed] [Full Text]

  • H. Watanabe, M. Kuraya, R. Kasukawa, H. Yanagisawa, M. Yanagisawa, and T. Fujita: Analysis of C5a receptor by monoclonal antibody. J. Immunol. Methods 185(1):19-29 (1995). [PubMed] [Full Text PDF]

  • T. Nagasawa, H. Yanagisawa, Y. Hasegawa, H. Kanma, and T. Abe: Polycythemia associated with primary systemic amyloidosis: elevated levels of hemopoietic factors and cytokines. Am. J. Hematol. 43(1):57-60 (1993). [PubMed] [Full Text PDF]

  • A. Sakamoto, M. Yanagisawa, T. Sakurai, Y. Takuwa, H. Yanagisawa, and T. Masaki: Cloning and functional expression of human cDNA for the ETB endothelin receptor. Biochem. Biophys. Res. Commun. 178(2):656-663 (1991). [PubMed] [Full Text PDF]

  • H. Yanagisawa, T. Nagasawa, S. Kuramochi, T. Abe, Y. Ikawa, and K. Todokoro: Constitutive expression of exogenous c-myb gene causes maturation block in monocyte-macrophage differentiation. Biochim. Biophys. Acta 1088(3):380-384 (1991). [PubMed] [Full Text PDF]

  • K. Todokoro, R. J. Watson, H. Higo, H. Amanuma, S. Kuramochi, H. Yanagisawa, and Y. Ikawa: Down-regulation of c-myb gene expression is a prerequisite for erythropoietin-induced erythroid differentiation. Proc. Natl. Acad. Sci. USA 85(23):8900-8904 (1988). [PubMed] [Full Text PDF]

  • J. D. Taurog, S. D. Maika, N. Satumtira, M. L. Dorris, I. L. McLean, H. Yanagisawa, A. Sayad, A. J. Stagg, G. M. Fox, A. L. O’Brien, M. Rehman, M. Zhou, A. L. Weiner, J. B. Splawski, J. A. Richardson, and R. E. Hammer: Inflammatory disease in HLA-B27 transgenic rats. Immunol. Rev. 169:209-223 (1999).  [PubMed] [Full Text PDF]

Reviews

  • Y. Yamashiro and H. Yanagisawa:The molecular mechanism of mechanotransduction in vascular homeostasis and disease. Clinical Science (2020) 134: 2399-2418.

  • S.Shin, H. Yanagisawa:Recent updates on the molecular network of elastic fiber formation. Essays In Biochemistry,EBC20180052ReviewArticle(pdf)[ESSAYS IN BIOCHEMISTRY(Abstract)]

  • L.Oinam, G.Changarathil, YX.Ngo, H. Yanagisawa, A.Sada:Epidermal stem cell lineages. Advances in Stem Cells and their Niches, Volume 3 (2019).[ScienceDirect(Abstract)]

  • H. Yanagisawa and J. Wageseil: Elastic fibers and biomechanics of the aorta: Insights from mouse studies. Matrix Biology, Epub ahead of print (2019). 

  • N. Funato and H. Yanagisawa: Deletion of the T-box transcription factor gene, Tbx1, in mice induces differential expression of genes associated with cleft palate in humans. Arch. Oral Biol. 95:149-155. DOI: 10.1016/j.archoralbio.2018.08.001. Epub ahead of print. (2018) [PubMed][Full Text]

  • Y. Yamashiro and H. Yanagisawa: Crossing Bridges between Extra- and Intra-Cellular Events in Thoracic Aortic Aneurysms. J. Atheroscler. Thromb. 25(2):99-110 (2017) [PubMed][Full Text]

  • N. Funato, M. Nakamura, and H. Yanagisawa: Molecular basis of cleft palates in mice. World J. Biol. Chem. 6(3):121-138 (2015). [PubMed][Full Text]

  • C. L. Papke, Y. Yamashiro, and H. Yanagisawa: MMP17/MT4-MMP and thoracic aortic aneurysms: OPNing new potential for effective treatment. Circ. Res. 117: 109-112 (2015).  [PubMed][Full Text]

  • C. L. Papke and H. Yanagisawa: Fibulin-4 and fibulin-5 in elastogenesis and beyond: Insights from mouse and human studies. Matrix Biol. 37:142-149 (2014). [PubMed] [Full Text]

  • H. Yanagisawa and E. C. Davis: Unraveling the mechanism of elastic fiber assembly: The roles of short fibulins. Int. J. Biochem. Cell Biol. 42(7): 1084–1093 (2010). [PubMed] [Full Text]

  • H. Yanagisawa, M. K. Schluterman, R. A. Brekken: Fibulin-5, an integrin-binding matricellular protein: its function in development and disease. J. Cell Commun. Signal.  3(3-4):337-347 (2009). [PubMed] [Full Text]

  • J. D. Taurog, S. D. Maika, N. Satumtira, M. L. Dorris, I. L. McLean, H. Yanagisawa, A. Sayad, A. J. Stagg, G. M. Fox, A. L. O’Brien, M. Rehman, M. Zhou, A. L. Weiner, J. B. Splawski, J. A. Richardson, and R. E. Hammer: Inflammatory disease in HLA-B27 transgenic rats. Immunol. Rev. 169:209-223 (1999).  [PubMed] [Full Text PDF]

Reviews in Japanese

  • 山城義人,柳沢裕美：大動脈瘤形成に関与するメカノトランスダクション機構,医学のあゆみ,269巻7号　2019年5月18日号「TOPICS」

  • 佐田 亜衣子：皮膚を作る幹細胞の同定・可視化技術, Cosmetic Stage 11(5): 11-20 (2017). [Cosmetic Stage 目次]

  • 佐田 亜衣子, Tudorita Tumbar：マウス表皮には分裂頻度の異なる２種類の幹細胞が共存する, 実験医学 34(14): 2700-2703 (2016). [実験医学 目次]

  • 佐田 亜衣子, Tudorita Tumbar：マウス表皮においては性質の異なる２種類の幹細胞が共存する, ライフサイエンス新着論文レビュー (2016). [Full Text]

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